Antiviral drug susceptibility of influenza viruses essay

This report demonstrates the importance of continuous monitoring of susceptibility of zoonotic influenza viruses to available and investigational antiviral drugs. Zanamivir may be preferred for prophylaxis because of its limited systemic absorption, but oseltamivir is a reasonable alternative, especially for women at increased risk for respiratory problems.

Favipiravir and ribavirin were each diluted to the final concentrations of 0. Of People Infected Estimated No. Frequently updated information on influenza activity, testing for influenza, and antiviral resistance is available from the CDC at www.

Longer durations of prophylaxis are often recommended for institutional and community outbreaks see Table 1. The nitazoxanide stock solution was prepared by dissolving 20 mg of nitazoxanide in 0.

For nitazoxanide, cell culture supernatants were collected at 48 h postinfection hpi and viral titers were determined in MDCK cells and expressed as log10 of tissue culture infectious dose TCID90 per ml.

An Introduction to Established and Emerging Zoonotic Diseases In general, the transfer of viruses to new hosts requires contact between a host and virus and amplification initiated by the infection of an individual which may lead to an outbreak. Briefly, cell monolayers were pretreated for 2 h with fludase at concentrations ranging from 0.

The major source of these onsets per annum is the emergence of an antigenically novel virus which the human population lack protective immunity against. Virus inoculum at a multiplicity of infection MOI of 0.

Meanwhile, animals are a source of panzootics which largely contribute to influenza pandemics. The live-attenuated vaccine is not recommended for use during the influenza season because it has been less effective than the inactivated vaccine in recent seasons. Individuals infected with A H3N2 v have mostly had mild illness with symptoms similar to that of seasonal influenza, which may result in the underreporting of A H3N2 v cases It can be considered after exposure for persons at high risk for complications who cannot receive the influenza vaccine or received it within the last 2 weeks, and for those who are unlikely to respond to vaccination.

Diarrhea, nausea, sinusitis, fever, and arthralgia have been reported with zanamivir. Human infection with a novel influenza type A virus is a disease reportable to the World Health Organization WHO under International Health Regulations 2 and has been a nationally notifiable condition in the United States since 3.

Sanger sequencing of NA genes was performed, and sequences were analyzed using BioEdit software 21as previously described 4. It has been estimated that the 13 zoonoses causing the greatest human morbidity and mortality result in the deaths of 2.In light of the high levels of resistance shown toward these two drugs, however, the threat to human health from influenza A viruses remains a significant problem (Laohpongspaisan et al., ; Rungrotmongkol et al., ; Cox and Subbarao, ).

Antiviral Drugs for Seasonal Influenza Download PDF: US English.

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Show Related Terms Hide Related Antiviral drugs can be used for treatment and prophylaxis of influenza. LV Gubareva et al. Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, Antiviral Res ;.

With a huge number of victims, 80 to million, sincethe influenza is considered as one of the most pandemic diseases ever. There are three types of influenza virus: influenza virus A, influenza virus B, and influenza virus c.

These are a subtypes of the virus family orthomyx-oviride. The Composition of Influenza A Viruses Influenza A viruses are of the Orthomyxoviridae genera and are all enveloped, negative-sense, single-stranded, segmented RNA viruses.

Within the lipid envelope of influenza A is an M2 protein, functioning as an ion channel, NA and HA molecules. Antiviral drug susceptibilities of seasonal human influenza viruses in Lebanon, –09 season Hassan Zaraket.genetic characteristics and antiviral susceptibility patterns of influenza samples collected in Lebanon during the –09 season were investigated.

Forty influenza virus samples were isolated from 89 nasopharyngeal.

resistant influenza viruses, alternative antiviral strategies have been developed. The sialidase activity in the virus neuramindase (NA) protein plays a critical role in the influenza virus replication cycle, and the design of NA protein inhibitors is currently one of the most common approaches in the development of anti-influenza virus drugs.

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Antiviral drug susceptibility of influenza viruses essay
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